Spread of Cryptococcus gattii into Pacific Northwest region of the United States.

Journal Article (Journal Article;Review)

Cryptococcus gattii has emerged as a human and animal pathogen in the Pacific Northwest. First recognized on Vancouver Island, British Columbia, Canada, it now involves mainland British Columbia, and Washington and Oregon in the United States. In Canada, the incidence of disease has been one of the highest worldwide. In the United States, lack of cryptococcal species identification and case surveillance limit our knowledge of C. gattii epidemiology. Infections in the Pacific Northwest are caused by multiple genotypes, but the major strain is genetically novel and may have emerged recently in association with unique mating or environmental changes. C. gattii disease affects immunocompromised and immunocompetent persons, causing substantial illness and death. Successful management requires an aggressive medical and surgical approach and consideration of potentially variable antifungal drug susceptibilities. We summarize the study results of a group of investigators and review current knowledge with the goal of increasing awareness and highlighting areas where further knowledge is required.

Full Text

Duke Authors

Cited Authors

  • Datta, K; Bartlett, KH; Baer, R; Byrnes, E; Galanis, E; Heitman, J; Hoang, L; Leslie, MJ; MacDougall, L; Magill, SS; Morshed, MG; Marr, KA; Cryptococcus gattii Working Group of the Pacific Northwest,

Published Date

  • August 2009

Published In

Volume / Issue

  • 15 / 8

Start / End Page

  • 1185 - 1191

PubMed ID

  • 19757550

Pubmed Central ID

  • PMC2815957

Electronic International Standard Serial Number (EISSN)

  • 1080-6059

Digital Object Identifier (DOI)

  • 10.3201/eid1508.081384


  • eng

Conference Location

  • United States