Evolution of pathogenicity and sexual reproduction in eight Candida genomes.

Published

Journal Article

Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.

Full Text

Duke Authors

Cited Authors

  • Butler, G; Rasmussen, MD; Lin, MF; Santos, MAS; Sakthikumar, S; Munro, CA; Rheinbay, E; Grabherr, M; Forche, A; Reedy, JL; Agrafioti, I; Arnaud, MB; Bates, S; Brown, AJP; Brunke, S; Costanzo, MC; Fitzpatrick, DA; de Groot, PWJ; Harris, D; Hoyer, LL; Hube, B; Klis, FM; Kodira, C; Lennard, N; Logue, ME; Martin, R; Neiman, AM; Nikolaou, E; Quail, MA; Quinn, J; Santos, MC; Schmitzberger, FF; Sherlock, G; Shah, P; Silverstein, KAT; Skrzypek, MS; Soll, D; Staggs, R; Stansfield, I; Stumpf, MPH; Sudbery, PE; Srikantha, T; Zeng, Q; Berman, J; Berriman, M; Heitman, J; Gow, NAR; Lorenz, MC; Birren, BW; Kellis, M; Cuomo, CA

Published Date

  • June 4, 2009

Published In

Volume / Issue

  • 459 / 7247

Start / End Page

  • 657 - 662

PubMed ID

  • 19465905

Pubmed Central ID

  • 19465905

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

Digital Object Identifier (DOI)

  • 10.1038/nature08064

Language

  • eng

Conference Location

  • England