Orchestration of sexual reproduction and virulence by the fungal mating-type locus.

Journal Article (Journal Article;Review)

The mating-type locus (MAT) orchestrates sexual reproduction in fungi. Sexual reproduction is related not only to fitness of an organism, but also correlated with virulence in certain pathogens. In the dandruff-associated fungus Malassesia globosa, although the sexual cycle remains to be discovered, whole genome analysis has led to the hypothesis that mating may occur on host skin. Furthermore, the MAT locus of M. globosa and U. hordei provides evidence that transitions between tetrapolar and bipolar systems have independently occurred. These results, together with studies recapitulating the ancestral tetrapolar mating system in Cryptococcus and the structure of MAT in related smut fungi, have furthered understanding on transitions between different mating systems and the evolution of MAT in the Basidiomycota.

Full Text

Duke Authors

Cited Authors

  • Hsueh, Y-P; Heitman, J

Published Date

  • December 2008

Published In

Volume / Issue

  • 11 / 6

Start / End Page

  • 517 - 524

PubMed ID

  • 18935978

Pubmed Central ID

  • PMC2622727

Electronic International Standard Serial Number (EISSN)

  • 1879-0364

Digital Object Identifier (DOI)

  • 10.1016/j.mib.2008.09.014


  • eng

Conference Location

  • England