Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.

Journal Article (Journal Article)

Fluconazole-FK506 or fluconazole-cyclosporine drug combinations were tested in an ex vivo Trichophyton mentagrophytes human skin infection model. Conidia colonization was monitored by scanning electron microscopy over a 7-day treatment period. The fluconazole-FK506 combination demonstrated the most obvious advantage over single-drug therapy by clearing conidia and protecting skin from damage at low drug concentrations.

Full Text

Duke Authors

Cited Authors

  • Onyewu, C; Eads, E; Schell, WA; Perfect, JR; Ullmann, Y; Kaufman, G; Horwitz, BA; Berdicevsky, I; Heitman, J

Published Date

  • October 2007

Published In

Volume / Issue

  • 51 / 10

Start / End Page

  • 3743 - 3746

PubMed ID

  • 17664323

Pubmed Central ID

  • PMC2043251

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/AAC.00492-07


  • eng

Conference Location

  • United States