Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.
Journal Article (Journal Article)
Fluconazole-FK506 or fluconazole-cyclosporine drug combinations were tested in an ex vivo Trichophyton mentagrophytes human skin infection model. Conidia colonization was monitored by scanning electron microscopy over a 7-day treatment period. The fluconazole-FK506 combination demonstrated the most obvious advantage over single-drug therapy by clearing conidia and protecting skin from damage at low drug concentrations.
- Onyewu, C; Eads, E; Schell, WA; Perfect, JR; Ullmann, Y; Kaufman, G; Horwitz, BA; Berdicevsky, I; Heitman, J
- October 2007
Volume / Issue
- 51 / 10
Start / End Page
- 3743 - 3746
Pubmed Central ID
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States