Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.
Journal Article (Journal Article)
In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.
Full Text
Duke Authors
Cited Authors
- Onyewu, C; Afshari, NA; Heitman, J
Published Date
- November 2006
Published In
Volume / Issue
- 50 / 11
Start / End Page
- 3963 - 3965
PubMed ID
- 16923949
Pubmed Central ID
- PMC1635197
International Standard Serial Number (ISSN)
- 0066-4804
Digital Object Identifier (DOI)
- 10.1128/AAC.00393-06
Language
- eng
Conference Location
- United States