Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.

Published

Journal Article

In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.

Full Text

Published version (via Digital Object Identifier)
Pubmed Central version

Duke Authors

Heitman, Joseph

Cited Authors

Onyewu, C; Afshari, NA; Heitman, J

Published Date

November 2006

Published In

Antimicrobial Agents and Chemotherapy

Volume / Issue

50 / 11

Start / End Page

3963 - 3965

PubMed ID

16923949

Pubmed Central ID

16923949

Electronic International Standard Serial Number (EISSN)

1098-6596

International Standard Serial Number (ISSN)

0066-4804

Digital Object Identifier (DOI)

10.1128/AAC.00393-06

Scholars@Duke