Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.
In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.
Onyewu, C; Afshari, NA; Heitman, J
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