Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.

Journal Article (Journal Article)

In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.

Full Text

Duke Authors

Cited Authors

  • Onyewu, C; Afshari, NA; Heitman, J

Published Date

  • November 2006

Published In

Volume / Issue

  • 50 / 11

Start / End Page

  • 3963 - 3965

PubMed ID

  • 16923949

Pubmed Central ID

  • PMC1635197

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/AAC.00393-06


  • eng

Conference Location

  • United States