Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients.

Journal Article (Journal Article)

In Candida albicans, calcineurin mediates tolerance to azole antifungal drugs, survival in serum, and virulence. In this study, we examined 24 Candida isolates from liver transplant recipients receiving a calcineurin inhibitor as a component of their immunosuppressive therapy. We were unable to detect a difference in susceptibility to calcineurin inhibitors in combination with fluconazole, serum, or calcium in these isolates.

Full Text

Duke Authors

Cited Authors

  • Reedy, JL; Husain, S; Ison, M; Pruett, TL; Singh, N; Heitman, J

Published Date

  • April 2006

Published In

Volume / Issue

  • 50 / 4

Start / End Page

  • 1573 - 1577

PubMed ID

  • 16569889

Pubmed Central ID

  • PMC1426937

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/AAC.50.4.1573-1577.2006


  • eng

Conference Location

  • United States