Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients.
Publication
, Journal Article
Reedy, JL; Husain, S; Ison, M; Pruett, TL; Singh, N; Heitman, J
Published in: Antimicrob Agents Chemother
April 2006
In Candida albicans, calcineurin mediates tolerance to azole antifungal drugs, survival in serum, and virulence. In this study, we examined 24 Candida isolates from liver transplant recipients receiving a calcineurin inhibitor as a component of their immunosuppressive therapy. We were unable to detect a difference in susceptibility to calcineurin inhibitors in combination with fluconazole, serum, or calcium in these isolates.
Duke Scholars
Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
April 2006
Volume
50
Issue
4
Start / End Page
1573 / 1577
Location
United States
Related Subject Headings
- Tacrolimus
- Serum
- Microbiology
- Liver Transplantation
- Immunosuppressive Agents
- Humans
- Fluconazole
- Drug Resistance, Fungal
- Candida albicans
- Calcium
Citation
APA
Chicago
ICMJE
MLA
NLM
Reedy, J. L., Husain, S., Ison, M., Pruett, T. L., Singh, N., & Heitman, J. (2006). Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients. Antimicrob Agents Chemother, 50(4), 1573–1577. https://doi.org/10.1128/AAC.50.4.1573-1577.2006
Reedy, Jennifer L., Shahid Husain, Michael Ison, Timothy L. Pruett, Nina Singh, and Joseph Heitman. “Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients.” Antimicrob Agents Chemother 50, no. 4 (April 2006): 1573–77. https://doi.org/10.1128/AAC.50.4.1573-1577.2006.
Reedy JL, Husain S, Ison M, Pruett TL, Singh N, Heitman J. Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients. Antimicrob Agents Chemother. 2006 Apr;50(4):1573–7.
Reedy, Jennifer L., et al. “Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients.” Antimicrob Agents Chemother, vol. 50, no. 4, Apr. 2006, pp. 1573–77. Pubmed, doi:10.1128/AAC.50.4.1573-1577.2006.
Reedy JL, Husain S, Ison M, Pruett TL, Singh N, Heitman J. Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients. Antimicrob Agents Chemother. 2006 Apr;50(4):1573–1577.
Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
April 2006
Volume
50
Issue
4
Start / End Page
1573 / 1577
Location
United States
Related Subject Headings
- Tacrolimus
- Serum
- Microbiology
- Liver Transplantation
- Immunosuppressive Agents
- Humans
- Fluconazole
- Drug Resistance, Fungal
- Candida albicans
- Calcium