The biology of the Cryptococcus neoformans species complex.


Journal Article (Review)

Cryptococcus neoformans is a major cause of fungal meningoencephalitis in immunocompromised patients. Despite recent advances in the genetics and molecular biology of C. neoformans, and improved techniques for molecular epidemiology, aspects of the ecology, population structure, and mode of reproduction of this environmental pathogen remain to be established. Application of recent insights into the life cycle of C. neoformans and its different ways of engaging in sexual reproduction under laboratory conditions has just begun to affect research on the ecology and epidemiology of this human pathogenic fungus. The melding of these disparate disciplines should yield rich dividends in our understanding of the evolution of microbial pathogens, providing insights relevant to diagnosis, treatment, and prevention.

Full Text

Duke Authors

Cited Authors

  • Lin, X; Heitman, J

Published Date

  • 2006

Published In

Volume / Issue

  • 60 /

Start / End Page

  • 69 - 105

PubMed ID

  • 16704346

Pubmed Central ID

  • 16704346

International Standard Serial Number (ISSN)

  • 0066-4227

Digital Object Identifier (DOI)

  • 10.1146/annurev.micro.60.080805.142102


  • eng

Conference Location

  • United States