Deciphering the model pathogenic fungus Cryptococcus neoformans.

Journal Article (Journal Article;Review)

Cryptococcus neoformans is a basidiomycete fungal pathogen of humans that has diverged considerably from other model fungi such as Neurospora crassa, Aspergillus nidulans, Saccharomyces cerevisiae and the common human fungal pathogen Candida albicans. The recent completion of the genome sequences of two related C. neoformans strains and the ongoing genome sequencing of three other divergent Cryptococcus strains with different virulence phenotypes and environmental distributions should improve our understanding of this important pathogen. We discuss the biology of C. neoformans in light of this genomic data, with a special emphasis on the role that evolution and sexual reproduction have in the complex relationships of the fungus with the environment and the host.

Full Text

Duke Authors

Cited Authors

  • Idnurm, A; Bahn, Y-S; Nielsen, K; Lin, X; Fraser, JA; Heitman, J

Published Date

  • October 2005

Published In

Volume / Issue

  • 3 / 10

Start / End Page

  • 753 - 764

PubMed ID

  • 16132036

International Standard Serial Number (ISSN)

  • 1740-1526

Digital Object Identifier (DOI)

  • 10.1038/nrmicro1245


  • eng

Conference Location

  • England