The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.

Journal Article (Journal Article)

In Candida albicans, calcineurin is essential for virulence and survival during membrane perturbation by azoles. Crz1 is a proposed downstream target of calcineurin based on studies of Saccharomyces cerevisiae. However, the in vitro phenotypes of C. albicans crz1/crz1 and calcineurin mutants differ and Crz1 is not required for virulence.

Full Text

Duke Authors

Cited Authors

  • Onyewu, C; Wormley, FL; Perfect, JR; Heitman, J

Published Date

  • December 2004

Published In

Volume / Issue

  • 72 / 12

Start / End Page

  • 7330 - 7333

PubMed ID

  • 15557662

Pubmed Central ID

  • PMC529171

International Standard Serial Number (ISSN)

  • 0019-9567

Digital Object Identifier (DOI)

  • 10.1128/IAI.72.12.7330-7333.2004


  • eng

Conference Location

  • United States