Modeling atrial arrhythmias: impact on clinical diagnosis and therapies.

Journal Article (Review;Journal Article)

Atrial arrhythmias are the most frequent sustained rhythm disorders in humans and often lead to severe complications such as heart failure and stroke. Despite the important insights provided by animal models into the mechanisms of atrial arrhythmias, direct translation of experimental findings to new therapies in patients has not been straightforward. With the advances in computer technology, large-scale electroanatomical computer models of the atria that integrate information from the molecular to organ scale have reached a level of sophistication that they can be used to interpret the outcome of experimental and clinical studies and aid in the rational design of therapies. This paper reviews the state-of-the-art of computer models of the electrical dynamics of the atria and discusses the evolving role of simulation in assisting the clinical diagnosis and treatment of atrial arrhythmias.

Full Text

Duke Authors

Cited Authors

  • Jacquemet, V; Kappenberger, L; Henriquez, CS

Published Date

  • January 2008

Published In

Volume / Issue

  • 1 /

Start / End Page

  • 94 - 114

PubMed ID

  • 22274901

Electronic International Standard Serial Number (EISSN)

  • 1941-1189

International Standard Serial Number (ISSN)

  • 1937-3333

Digital Object Identifier (DOI)

  • 10.1109/rbme.2008.2008242


  • eng