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Patterns and predictors of discharge statin prescription among hospitalized patients with intracerebral hemorrhage.

Publication ,  Journal Article
Ovbiagele, B; Schwamm, LH; Smith, EE; Hernandez, AF; Olson, DM; Pan, W; Fonarow, GC; Saver, JL
Published in: Stroke
October 2010

BACKGROUND AND PURPOSE: Many patients hospitalized with intracerebral hemorrhage are at high future risk for ischemic events and may benefit from stain therapy. However, little is known about patterns of statin prescription among patients with intracerebral hemorrhage, especially after the finding of higher hemorrhagic stroke risk in the statin treatment arm of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. We evaluated recent nationwide trends in discharge statin treatment after intracerebral hemorrhage hospitalization. METHODS: Using data from 25 673 patients with hemorrhagic stroke admitted to Get With Guidelines-Stroke participating hospitals between January 1, 2005, and December 31, 2007, we assessed factors associated with discharge statin prescription, including treatment over time and in relation to dissemination of the SPARCL results. Piecewise logistic multivariable regression models were fit to track statin use in various periods. RESULTS: Mean age was 67.9±15 years, 48.1% female, and discharge statin treatment in 39.5%. Variables independently associated with lower discharge statin use included female sex (OR 0.87, 95% CI, 0.82 to 0.93), prior stroke/transient ischemic attack (OR 0.85, 95% CI, 0.78 to 0.92), academic center (OR 0.87, 95% CI, 0.82 to 0.93), and Midwest region (OR 0.65, 95% CI, 0.56 to 0.80). Statin prescription climbed over the study period from 66.9% to 74.5% (P<0.001) among eligible patients with a decrease during SPARCL reporting (P=0.03) and then a return to prior levels thereafter. CONCLUSIONS: Discharge statin prescription among hospitalized patients with intracerebral hemorrhage has modestly risen over time. The clinical implications of this care pattern among patients with intracerebral hemorrhage require further study.

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Published In

Stroke

DOI

EISSN

1524-4628

Publication Date

October 2010

Volume

41

Issue

10

Start / End Page

2271 / 2277

Location

United States

Related Subject Headings

  • Sex Factors
  • Practice Patterns, Physicians'
  • Patient Discharge
  • Odds Ratio
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Ovbiagele, B., Schwamm, L. H., Smith, E. E., Hernandez, A. F., Olson, D. M., Pan, W., … Saver, J. L. (2010). Patterns and predictors of discharge statin prescription among hospitalized patients with intracerebral hemorrhage. Stroke, 41(10), 2271–2277. https://doi.org/10.1161/STROKEAHA.110.593228
Ovbiagele, Bruce, Lee H. Schwamm, Eric E. Smith, Adrian F. Hernandez, DaiWai M. Olson, Wenqin Pan, Gregg C. Fonarow, and Jeffrey L. Saver. “Patterns and predictors of discharge statin prescription among hospitalized patients with intracerebral hemorrhage.Stroke 41, no. 10 (October 2010): 2271–77. https://doi.org/10.1161/STROKEAHA.110.593228.
Ovbiagele B, Schwamm LH, Smith EE, Hernandez AF, Olson DM, Pan W, et al. Patterns and predictors of discharge statin prescription among hospitalized patients with intracerebral hemorrhage. Stroke. 2010 Oct;41(10):2271–7.
Ovbiagele, Bruce, et al. “Patterns and predictors of discharge statin prescription among hospitalized patients with intracerebral hemorrhage.Stroke, vol. 41, no. 10, Oct. 2010, pp. 2271–77. Pubmed, doi:10.1161/STROKEAHA.110.593228.
Ovbiagele B, Schwamm LH, Smith EE, Hernandez AF, Olson DM, Pan W, Fonarow GC, Saver JL. Patterns and predictors of discharge statin prescription among hospitalized patients with intracerebral hemorrhage. Stroke. 2010 Oct;41(10):2271–2277.

Published In

Stroke

DOI

EISSN

1524-4628

Publication Date

October 2010

Volume

41

Issue

10

Start / End Page

2271 / 2277

Location

United States

Related Subject Headings

  • Sex Factors
  • Practice Patterns, Physicians'
  • Patient Discharge
  • Odds Ratio
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Female