Biochemistry and immunology of poly(ethylene glycol)-modified adenosine deaminase (PEG-ADA)


Journal Article

Enzyme conjugation with polyethylene glycol (PEG) is one method for solving problems in enzyme replacement therapy for metabolic diseases. An intramuscular injection of bovine adenosine deaminase (ADA) conjugated with 5 kDa mono-methoxy PEG was used to treat severe combined immunodeficiency (SCID). Pharmacokinetics were assessed by monitoring plasma ADA activity during treatment, while the immunologic response to PEG-ADA was monitored by ELISA.

Duke Authors

Cited Authors

  • Hershfield, MS

Published Date

  • April 1, 1997

Published In

Volume / Issue

  • 38 / 1

Start / End Page

  • 567 -

International Standard Serial Number (ISSN)

  • 0032-3934

Citation Source

  • Scopus