Maintenance therapy with fluoxetine in posttraumatic stress disorder: a placebo-controlled discontinuation study.
Journal Article (Clinical Trial;Journal Article)
The effect of fluoxetine (FLU) in posttraumatic stress disorder was studied in a one-year trial. Subjects received open-label treatment for 6 months, followed by double-blind randomized treatment with FLU or placebo (PBO) for 6 months. Rates of relapse were compared using the Clinical Global Impressions of Improvement. One hundred twenty-three subjects entered open-label treatment, of whom 114 returned at least once. Sixty-two subjects were randomized to receive FLU or PBO, of whom 57 returned at least once and were analyzed. The dose of FLU ranged from 10 to 60 mg/d; at randomization, mean doses were 48.6 and 42.1 mg for FLU and PBO groups. Rates of relapse were 22% for FLU versus 50% for PBO (P = 0.02), and time to relapse on FLU was longer than for PBO (P = 0.02, log-rank statistic). The odds ratio for relapse on PBO relative to FLU was 3.50. No significant differences were found on other measures. Fluoxetine was well tolerated during double-blind treatment.
- Davidson, JRT; Connor, KM; Hertzberg, MA; Weisler, RH; Wilson, WH; Payne, VM
- April 2005
Volume / Issue
- 25 / 2
Start / End Page
- 166 - 169
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States