Transmitted antiretroviral drug resistance among acute and recent HIV infections in North Carolina from 1998 to 2007.

Published

Journal Article

Transmitted drug resistance (TDR) limits antiretroviral options and thus complicates the management of HIV-positive patients. HIV disproportionately affects the southern US, but available national estimates of TDR prevalence principally reflect large metropolitan centres outside this region.The Duke/UNC Acute HIV Program has collected data on acute or recent HIV infections (ARHI) in North Carolina since 1998. Acute infections represent antibody-negative, RNA-positive patients. Recent infection was determined by history of HIV testing or concordance between detuned ELISA and antibody avidity assays. Genotypic sequence data from the earliest collected pretreatment plasma samples were analysed with the Stanford HIV Database and screened for surveillance drug resistance mutations (SDRMs).A total of 253 individuals with ARHI between May 1998 and May 2007 had complete genotypic sequence data for analysis; 39.5% were acute infections, 78.7% were male, 64.8% were non-White and 53.8% were men who have sex with men. The overall prevalence of TDR was 17.8%, with SDRMs for non-nucleoside/nucleotide reverse transcriptase inhibitors (NNRTIs) in 9.5% of the cohort. Mutations for nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) were detected in 7.5% and for protease inhibitors (PIs) in 3.2%. K103N was the most common mutation (7.5%). Thymidine analogue mutations were found in 4.7% of samples; the most common PI SDRM was L90M (2.4%). Dual- or triple-class antiretroviral resistance was rare, encountered in only six (2.4%) samples.The prevalence of TDR in North Carolina is similar to estimates from the US metropolitan areas. These findings have implications for initial regimen selection and secondary prevention efforts outside of large, metropolitan HIV epicentres.

Full Text

Cited Authors

  • Hurt, CB; McCoy, SI; Kuruc, J; Nelson, JA; Kerkau, M; Fiscus, S; McGee, K; Sebastian, J; Leone, P; Pilcher, C; Hicks, C; Eron, J

Published Date

  • January 2009

Published In

Volume / Issue

  • 14 / 5

Start / End Page

  • 673 - 678

PubMed ID

  • 19704170

Pubmed Central ID

  • 19704170

Electronic International Standard Serial Number (EISSN)

  • 2040-2058

International Standard Serial Number (ISSN)

  • 1359-6535

Language

  • eng