Treatment response to ritonavir-boosted tipranavir versus ritonavir-boosted lopinavir in HIV-1 patients with higher lopinavir mutation scores.


Journal Article

Week 48 HIV-RNA treatment response to the protease inhibitor tipranavir co-administered with ritonavir was compared with that of lopinavir co-administered with ritonavir in patients whose baseline isolates had varying lopinavir genotypic mutation scores. With increasing lopinavir mutation scores, the proportion of patients achieving a week 48 treatment response was increased in the tipranavir/ritonavir compared with the lopinavir/ritonavir arm. Tipranavir/ritonavir therapy improves treatment response rates compared with lopinavir/ritonavir in patients whose viruses have reduced susceptibility to lopinavir/ritonavir.

Full Text

Cited Authors

  • Walmsley, SL; Cotte, L; Rusconi, S; Ward, DJ; Hicks, CB; Meier, U; Valdez, H; Boucher, CA

Published Date

  • October 2007

Published In

Volume / Issue

  • 21 / 16

Start / End Page

  • 2245 - 2248

PubMed ID

  • 18090054

Pubmed Central ID

  • 18090054

Electronic International Standard Serial Number (EISSN)

  • 1473-5571

International Standard Serial Number (ISSN)

  • 0269-9370

Digital Object Identifier (DOI)

  • 10.1097/qad.0b013e3282ef6db7


  • eng