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Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas).

Publication ,  Journal Article
Denton, DL; Wheelock, CE; Murray, SA; Deanovic, LA; Hammock, BD; Hinton, DE
Published in: Environmental toxicology and chemistry
February 2003

California (USA) agriculture employs pyrethroid and organophosphate insecticides to control insects in orchards and other crops. Diazinon and esfenvalerate were selected for this study because of their application overlaps. Toxicological and biochemical responses of larval fathead minnows (Pimephales promelas) exposed singly and in combinations to esfenvalerate and diazinon were determined. Exposures were 96-h static renewal tests that used standard U.S. Environmental Protection Agency acute toxicity test methods. After pesticide exposures, larvae were evaluated for carboxylesterase and acetylcholinesterase activity, and histopathological effects. Carboxylesterase activity was examined because of its potential influence on the toxicity of both organophosphates and pyrethroids. In vivo studies demonstrated that diazinon significantly inhibited carboxylesterase activity at nominal water concentrations as low as 50 microg/L. However, esfenvalerate did not affect carboxylesterase activity at any concentration tested. Liver glycogen depletion was the only histopathological effect observed; this effect was demonstrated with the individual pesticides and pesticide combinations (i.e., mixtures). The combinations of diazinon and esfenvalerate causing acute toxicity to fathead minnow larvae appeared to be greater than additive (i.e., synergistic) in all three tests.

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Published In

Environmental toxicology and chemistry

DOI

EISSN

1552-8618

ISSN

0730-7268

Publication Date

February 2003

Volume

22

Issue

2

Start / End Page

336 / 341

Related Subject Headings

  • Water Pollutants, Chemical
  • Toxicity Tests, Acute
  • Time Factors
  • Pyrethrins
  • Nitriles
  • Lethal Dose 50
  • Larva
  • Enzyme Inhibitors
  • Environmental Sciences
  • Drug Synergism
 

Citation

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Denton, D. L., Wheelock, C. E., Murray, S. A., Deanovic, L. A., Hammock, B. D., & Hinton, D. E. (2003). Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas). Environmental Toxicology and Chemistry, 22(2), 336–341. https://doi.org/10.1002/etc.5620220214
Denton, Debra L., Craig E. Wheelock, Shauna A. Murray, Linda A. Deanovic, Bruce D. Hammock, and David E. Hinton. “Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas).Environmental Toxicology and Chemistry 22, no. 2 (February 2003): 336–41. https://doi.org/10.1002/etc.5620220214.
Denton DL, Wheelock CE, Murray SA, Deanovic LA, Hammock BD, Hinton DE. Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas). Environmental toxicology and chemistry. 2003 Feb;22(2):336–41.
Denton, Debra L., et al. “Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas).Environmental Toxicology and Chemistry, vol. 22, no. 2, Feb. 2003, pp. 336–41. Epmc, doi:10.1002/etc.5620220214.
Denton DL, Wheelock CE, Murray SA, Deanovic LA, Hammock BD, Hinton DE. Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas). Environmental toxicology and chemistry. 2003 Feb;22(2):336–341.
Journal cover image

Published In

Environmental toxicology and chemistry

DOI

EISSN

1552-8618

ISSN

0730-7268

Publication Date

February 2003

Volume

22

Issue

2

Start / End Page

336 / 341

Related Subject Headings

  • Water Pollutants, Chemical
  • Toxicity Tests, Acute
  • Time Factors
  • Pyrethrins
  • Nitriles
  • Lethal Dose 50
  • Larva
  • Enzyme Inhibitors
  • Environmental Sciences
  • Drug Synergism