Architectural pattern, tissue and cellular morphology in livers of fishes: relationship to experimentally-induced neoplastic responses.

Journal Article (Review;Journal Article)

The teleost liver is one of the most sensitive organs to show alteration in biochemistry, physiology and structure following exposure to various types of environmental pollutants. Despite the importance of this organ to environmental toxicology and to ecotoxicology where biomarkers of exposure and of deleterious effect are found, the architectural pattern is not well known. This chapter reviews an architectural plan for teleost liver and compares that to the often cited mammalian pattern. Hepatic tubules composed principally of hepatocytes and biliary epithelial cells are in close proximity to lacunae which are of mesodermal origin. As is described, the tubule and lacunae concepts provide a means to better interpret morphologic alterations following exposure. These concepts are used to illustrate features of the chronic toxicity following exposure to proven carcinogens.

Full Text

Duke Authors

Cited Authors

  • Hinton, DE; Couch, JA

Published Date

  • January 1998

Published In

Volume / Issue

  • 86 /

Start / End Page

  • 141 - 164

PubMed ID

  • 9949876

Electronic International Standard Serial Number (EISSN)

  • 2504-3684

International Standard Serial Number (ISSN)

  • 1023-294X

Digital Object Identifier (DOI)

  • 10.1007/978-3-0348-8853-0_4


  • eng