Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.

Journal Article (Journal Article)

Calorie restriction results in leanness, which is linked to metabolic conditions that favor longevity. We show here that deficiency of the triglyceride synthesis enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), which promotes leanness, also extends longevity without limiting food intake. Female DGAT1-deficient mice were protected from age-related increases in body fat, tissue triglycerides, and inflammation in white adipose tissue. This protection was accompanied by increased mean and maximal life spans of ~25% and ~10%, respectively. Middle-agedDgat1-/- mice exhibited several features associated with longevity, including decreased levels of circulating insulin growth factor 1 (IGF1) and reduced fecundity. Thus, deletion of DGAT1 in mice provides a model of leanness and extended lifespan that is independent of calorie restriction.

Full Text

Duke Authors

Cited Authors

  • Streeper, RS; Grueter, CA; Salomonis, N; Cases, S; Levin, MC; Koliwad, SK; Zhou, P; Hirschey, MD; Verdin, E; Farese, RV

Published Date

  • January 2012

Published In

Volume / Issue

  • 4 / 1

Start / End Page

  • 13 - 27

PubMed ID

  • 22291164

Pubmed Central ID

  • PMC3292902

Electronic International Standard Serial Number (EISSN)

  • 1945-4589

Digital Object Identifier (DOI)

  • 10.18632/aging.100424


  • eng

Conference Location

  • United States