Skip to main content

SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2.

Publication ,  Journal Article
Hirschey, MD; Shimazu, T; Capra, JA; Pollard, KS; Verdin, E
Published in: Aging (Albany NY)
June 2011

SIRT1 and SIRT3 are NAD+-dependent protein deacetylases that are evolutionarily conserved across mammals. These proteins are located in the cytoplasm/nucleus and mitochondria, respectively. Previous reports demonstrated that human SIRT1 deacetylates Acetyl-CoA Synthase 1 (AceCS1) in the cytoplasm, whereas SIRT3 deacetylates the homologous Acetyl-CoA Synthase 2 (AceCS2) in the mitochondria. We recently showed that 3-hydroxy-3-methylglutaryl CoA synthase 2 (HMGCS2) is deacetylated by SIRT3 in mitochondria, and we demonstrate here that SIRT1 deacetylates the homologous 3-hydroxy-3-methylglutaryl CoA synthase 1 (HMGCS1) in the cytoplasm. This novel pattern of substrate homology between cytoplasmic SIRT1 and mitochondrial SIRT3 suggests that considering evolutionary relationships between the sirtuins and their substrates may help to identify and understand the functions and interactions of this gene family. In this perspective, we take a first step by characterizing the evolutionary history of the sirtuins and these substrate families.

Duke Scholars

Published In

Aging (Albany NY)

DOI

EISSN

1945-4589

Publication Date

June 2011

Volume

3

Issue

6

Start / End Page

635 / 642

Location

United States

Related Subject Headings

  • Sirtuin 3
  • Sirtuin 1
  • Phylogeny
  • Isoenzymes
  • Hydroxymethylglutaryl-CoA Synthase
  • Humans
  • Evolution, Molecular
  • Developmental Biology
  • Animals
  • Acetylation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hirschey, M. D., Shimazu, T., Capra, J. A., Pollard, K. S., & Verdin, E. (2011). SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2. Aging (Albany NY), 3(6), 635–642. https://doi.org/10.18632/aging.100339
Hirschey, Matthew D., Tadahiro Shimazu, John A. Capra, Katherine S. Pollard, and Eric Verdin. “SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2.Aging (Albany NY) 3, no. 6 (June 2011): 635–42. https://doi.org/10.18632/aging.100339.
Hirschey MD, Shimazu T, Capra JA, Pollard KS, Verdin E. SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2. Aging (Albany NY). 2011 Jun;3(6):635–42.
Hirschey, Matthew D., et al. “SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2.Aging (Albany NY), vol. 3, no. 6, June 2011, pp. 635–42. Pubmed, doi:10.18632/aging.100339.
Hirschey MD, Shimazu T, Capra JA, Pollard KS, Verdin E. SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2. Aging (Albany NY). 2011 Jun;3(6):635–642.

Published In

Aging (Albany NY)

DOI

EISSN

1945-4589

Publication Date

June 2011

Volume

3

Issue

6

Start / End Page

635 / 642

Location

United States

Related Subject Headings

  • Sirtuin 3
  • Sirtuin 1
  • Phylogeny
  • Isoenzymes
  • Hydroxymethylglutaryl-CoA Synthase
  • Humans
  • Evolution, Molecular
  • Developmental Biology
  • Animals
  • Acetylation