Monitoring immunity to cancer vaccines
The potential use of vaccines to treat and prevent cancer has developed into an area of intense research. Great success has been achieved historically with vaccines against infectious agents, and observations such as a graft vs leukemia effect and spontaneous regression of tumors indicate the ability of the immune system to attack tumor cells. Vaccines are also an attractive option for cancer, because of the low level of side effects and complications compared with traditional cancer therapies. Further, vaccines can be combined with other immunomodulatory agents, such as cytokines and co-stimulatory factors, to further enhance the antitumor immune response.
Hobeika, AC; Clay, TM; Morse, MA
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