Isolation and characterization of the mouse homolog of the preprodynorphin (Pdyn) gene.


Journal Article

We have isolated and sequenced the mouse preprodynorphin gene (Pdyn). The Pdyn gene can encode for six biologically active dynorphin peptides. The predicted mouse preprodynorphin has 90%, 67%, and 66% identity with the predicted rat, porcine, and human preprodynorphins, respectively. Using an RT-PCR technique, we show that the Pdyn gene starts being expressed at embryonic day 12.5, with a steep increase of expression by embryonic day 14.5; in the adult mouse it is expressed in the brain, but not in liver, heart, spleen, or kidney.

Full Text

Cited Authors

  • Sharifi, N; Ament, M; Brennan, MB; Hochgeschwender, U

Published Date

  • June 1999

Published In

Volume / Issue

  • 33 / 3

Start / End Page

  • 236 - 238

PubMed ID

  • 10657497

Pubmed Central ID

  • 10657497

Electronic International Standard Serial Number (EISSN)

  • 1532-2785

International Standard Serial Number (ISSN)

  • 0143-4179

Digital Object Identifier (DOI)

  • 10.1054/npep.1999.0023


  • eng