Dominance of one T-cell receptor in the H-2Kb/TNP response.

Published

Journal Article

T-cell receptors (TCRs) recognize foreign antigens in the context of major histocompatibility complex (MHC)-encoded cell surface proteins. These receptors are heterogeneous, dimeric glycoproteins composed of disulphide linked alpha- and beta-chains. We analysed the diversity of TCRs in a collection of H-2Kb-restricted, 2,4,6-trinitrophenyl (TNP)-specific (H-2Kb/TNP) cytotoxic T-cell (Tc) clones from C57BL/6 mice. Investigation of the beta-chain messenger RNAs revealed that nearly half of these independent clones expressed an identical beta-chain gene. We show here that almost all the Tc clones expressing the predominant beta-chain gene also express an identical alpha-chain gene. These results show that a strong selective pressure acted on the Tc population, resulting in a skewing of the TCR repertoire for H-2Kb/TNP and in the dominant expression of one TCR with this specificity. Possible explanations for this skewing include antigen-driven clonal expansion and network interactions.

Full Text

Cited Authors

  • Hochgeschwender, U; Simon, HG; Weltzien, HU; Bartels, F; Becker, A; Epplen, JT

Published Date

  • March 1, 1987

Published In

Volume / Issue

  • 326 / 6110

Start / End Page

  • 307 - 309

PubMed ID

  • 3493439

Pubmed Central ID

  • 3493439

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/326307a0

Language

  • eng