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Rethinking the coagulation cascade.

Publication ,  Journal Article
Hoffman, MM; Monroe, DM
Published in: Curr Hematol Rep
September 2005

The concept of coagulation as a "cascade" of proteolytic reactions was a conceptual breakthrough in understanding how the coagulation process acts as a biologic amplifier. The model that it evolved into, with "extrinsic" and "intrinsic" pathways meeting in a common pathway, delineates the interactions between the coagulation proteins and provides a framework for interpreting the common screening coagulation tests. The coagulation "cascade" has significant limitations as a model of how hemostasis occurs in vivo, however. This article describes how the modern view of hemostasis has evolved to emphasize the role of cells in controlling and directing the coagulation reactions. It also highlights how host factors that are not part of the coagulation process per se can influence the effectiveness of coagulation.

Duke Scholars

Published In

Curr Hematol Rep

EISSN

1541-0714

Publication Date

September 2005

Volume

4

Issue

5

Start / End Page

391 / 396

Location

United States

Related Subject Headings

  • Thromboplastin
  • Humans
  • Hemostasis
  • Endothelium, Vascular
  • Blood Platelets
  • Blood Coagulation
 

Citation

APA
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ICMJE
MLA
NLM
Hoffman, M. M., & Monroe, D. M. (2005). Rethinking the coagulation cascade. Curr Hematol Rep, 4(5), 391–396.
Hoffman, Maureane M., and Dougald M. Monroe. “Rethinking the coagulation cascade.Curr Hematol Rep 4, no. 5 (September 2005): 391–96.
Hoffman MM, Monroe DM. Rethinking the coagulation cascade. Curr Hematol Rep. 2005 Sep;4(5):391–6.
Hoffman, Maureane M., and Dougald M. Monroe. “Rethinking the coagulation cascade.Curr Hematol Rep, vol. 4, no. 5, Sept. 2005, pp. 391–96.
Hoffman MM, Monroe DM. Rethinking the coagulation cascade. Curr Hematol Rep. 2005 Sep;4(5):391–396.

Published In

Curr Hematol Rep

EISSN

1541-0714

Publication Date

September 2005

Volume

4

Issue

5

Start / End Page

391 / 396

Location

United States

Related Subject Headings

  • Thromboplastin
  • Humans
  • Hemostasis
  • Endothelium, Vascular
  • Blood Platelets
  • Blood Coagulation