Epithelial progenitor cells of the embryonic lung and the role of microRNAs in their proliferation.

Journal Article

The entire epithelium of the lung is generated from a small pool of undifferentiated progenitor cells. At least during the early stages of development these reside in the distal tips of the embryonic lung. They respond to multiple signals from the surrounding mesenchyme and play a critical role as morphogenetic organizing centers. In addition, they proliferate rapidly and give rise to daughter cells that differentiate into all the specialized epithelial cells types of the newborn lung. Despite the importance of the progenitor cells, we still know relatively little about the mechanisms controlling their proliferation, morphogenesis, and developmental fate. Here, we discuss new data on the potential role of microRNAs in co-coordinately regulating multiple signaling pathways in embryonic progenitor cells. In particular, our recent transgenic experiments suggest that microRNAs encoded by the miR-17-92 cluster positively promote proliferation of epithelial progenitor cells and inhibit their differentiation. We speculate on how this information might be exploited therapeutically in the long term.

Full Text

Duke Authors

Cited Authors

  • Lu, Y; Okubo, T; Rawlins, E; Hogan, BLM

Published Date

  • April 15, 2008

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 300 - 304

PubMed ID

  • 18403323

Pubmed Central ID

  • PMC2645240

International Standard Serial Number (ISSN)

  • 1546-3222

Digital Object Identifier (DOI)

  • 10.1513/pats.200710-162DR


  • eng

Conference Location

  • United States