Sox2 is required for development of taste bud sensory cells.
Journal Article (Journal Article)
Sox2 is expressed in basal epithelial cells of the tongue, with high levels in taste bud placodes, fungiform papillae, and mature taste cells, and low levels in filiform papillae. High Sox2 expression appears to lie downstream from canonical Wnt signaling. In hypomorphic Sox2(EGFP/LP) embryos, placodes form but no mature taste buds develop. In contrast, transgenic overexpression of Sox2 in the basal cells inhibits differentiation of filiform keratinocytes. Together, our loss-of-function and gain-of-function studies suggest that Sox2 functions in a dose-dependent manner to regulate the differentiation of endodermal progenitor cells of the tongue into taste bud sensory cells versus keratinocytes.
Full Text
Duke Authors
Cited Authors
- Okubo, T; Pevny, LH; Hogan, BLM
Published Date
- October 1, 2006
Published In
Volume / Issue
- 20 / 19
Start / End Page
- 2654 - 2659
PubMed ID
- 17015430
Pubmed Central ID
- PMC1578692
International Standard Serial Number (ISSN)
- 0890-9369
Digital Object Identifier (DOI)
- 10.1101/gad.1457106
Language
- eng
Conference Location
- United States