Sox2 is required for development of taste bud sensory cells.

Published

Journal Article

Sox2 is expressed in basal epithelial cells of the tongue, with high levels in taste bud placodes, fungiform papillae, and mature taste cells, and low levels in filiform papillae. High Sox2 expression appears to lie downstream from canonical Wnt signaling. In hypomorphic Sox2(EGFP/LP) embryos, placodes form but no mature taste buds develop. In contrast, transgenic overexpression of Sox2 in the basal cells inhibits differentiation of filiform keratinocytes. Together, our loss-of-function and gain-of-function studies suggest that Sox2 functions in a dose-dependent manner to regulate the differentiation of endodermal progenitor cells of the tongue into taste bud sensory cells versus keratinocytes.

Full Text

Duke Authors

Cited Authors

  • Okubo, T; Pevny, LH; Hogan, BLM

Published Date

  • October 1, 2006

Published In

Volume / Issue

  • 20 / 19

Start / End Page

  • 2654 - 2659

PubMed ID

  • 17015430

Pubmed Central ID

  • 17015430

International Standard Serial Number (ISSN)

  • 0890-9369

Digital Object Identifier (DOI)

  • 10.1101/gad.1457106

Language

  • eng

Conference Location

  • United States