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The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development.

Publication ,  Journal Article
Mattiske, D; Kume, T; Hogan, BLM
Published in: Dev Biol
February 15, 2006

Foxc1 encodes a forkhead/winged helix transcription factor expressed in many embryonic tissues. Previous studies have investigated defects in the urogenital system of Foxc1 null mutants, but the mechanisms underlying the abnormal development of the gonad have not been explored. From earliest stages, the mutant ovaries are smaller than normal, with fewer germ cells and disorganized somatic issue. No bursa membrane is formed, and the oviduct remains uncoiled. Although germ cells are specified correctly, many of them do not migrate to the gonadal ridge, remaining trapped in the hindgut. Consequently, the number initially reaching the gonad is less than 25% of normal. Once in the ovary, germ cells proliferate normally, but the supporting somatic cells are not organized correctly. Since mutant embryos die at birth, further development was followed in ovaries grafted underneath the kidney capsule of ovariectomized females. Transplanted ovaries display normal folliculogenesis up to preantral stages. However, no follicles develop beyond early antral stages. Mutant follicles are often polyovulatory and have disrupted theca and granulosa cell layers. We conclude that alongside its previously known roles in kidney, cardiovascular and eye development, Foxc1 has essential functions during at least two stages of gonad development-germ cell migration and folliculogenesis.

Duke Scholars

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Published In

Dev Biol

DOI

ISSN

0012-1606

Publication Date

February 15, 2006

Volume

290

Issue

2

Start / End Page

447 / 458

Location

United States

Related Subject Headings

  • Time Factors
  • Theca Cells
  • Reverse Transcriptase Polymerase Chain Reaction
  • Protein Structure, Tertiary
  • Ovary
  • Ovarian Follicle
  • Mutation
  • Mice, Transgenic
  • Mice, SCID
  • Mice
 

Citation

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Mattiske, D., Kume, T., & Hogan, B. L. M. (2006). The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development. Dev Biol, 290(2), 447–458. https://doi.org/10.1016/j.ydbio.2005.12.007
Mattiske, Deidre, Tsutomu Kume, and Brigid L. M. Hogan. “The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development.Dev Biol 290, no. 2 (February 15, 2006): 447–58. https://doi.org/10.1016/j.ydbio.2005.12.007.
Mattiske, Deidre, et al. “The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development.Dev Biol, vol. 290, no. 2, Feb. 2006, pp. 447–58. Pubmed, doi:10.1016/j.ydbio.2005.12.007.
Journal cover image

Published In

Dev Biol

DOI

ISSN

0012-1606

Publication Date

February 15, 2006

Volume

290

Issue

2

Start / End Page

447 / 458

Location

United States

Related Subject Headings

  • Time Factors
  • Theca Cells
  • Reverse Transcriptase Polymerase Chain Reaction
  • Protein Structure, Tertiary
  • Ovary
  • Ovarian Follicle
  • Mutation
  • Mice, Transgenic
  • Mice, SCID
  • Mice