An essential role of Bmp4 in the atrioventricular septation of the mouse heart.

Published

Journal Article

Proper septation and valvulogenesis during cardiogenesis depend on interactions between the myocardium and the endocardium. By combining use of a hypomorphic Bone morphogenetic protein 4 (Bmp4) allele with conditional gene inactivation, we here identify Bmp4 as a signal from the myocardium directly mediating atrioventricular septation. Defects in this process cause one of the most common human congenital heart abnormalities, atrioventricular canal defect (AVCD). The spectrum of defects obtained through altering Bmp4 expression in the myocardium recapitulates the range of AVCDs diagnosed in patients, thus providing a useful genetic model with AVCD as the primary defect.

Full Text

Duke Authors

Cited Authors

  • Jiao, K; Kulessa, H; Tompkins, K; Zhou, Y; Batts, L; Baldwin, HS; Hogan, BLM

Published Date

  • October 1, 2003

Published In

Volume / Issue

  • 17 / 19

Start / End Page

  • 2362 - 2367

PubMed ID

  • 12975322

Pubmed Central ID

  • 12975322

Electronic International Standard Serial Number (EISSN)

  • 1549-5477

International Standard Serial Number (ISSN)

  • 0890-9369

Digital Object Identifier (DOI)

  • 10.1101/gad.1124803

Language

  • eng