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Differential gene expression in the distal tip endoderm of the embryonic mouse lung.

Publication ,  Journal Article
Liu, Y; Hogan, BLM
Published in: Gene Expr Patterns
December 2002

During the early development of the mouse lung a number of genes encoding signaling molecules are differentially expressed in the epithelium and mesenchyme of the distal buds. Evidence suggests they play a role in regulating the stereotypic processes of bud outgrowth and branching as well as proximal-distal patterning of both cell layers. To better understand the mechanisms underlying branching morphogenesis, a subtractive hybridization and differential screen was carried out for genes preferentially expressed in the epithelium at the tips of embryonic day 11.5 lung buds, versus more proximal regions. Twenty genes were identified, assigned to different categories based on sequence analysis, and their distal expression confirmed by whole-mount in situ hybridization.

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Published In

Gene Expr Patterns

DOI

ISSN

1567-133X

Publication Date

December 2002

Volume

2

Issue

3-4

Start / End Page

229 / 233

Location

Netherlands

Related Subject Headings

  • Transcription Factors
  • Thrombospondin 1
  • Signal Transduction
  • Receptors, Cell Surface
  • Protein Transport
  • Mice
  • Lung
  • Ligands
  • Gene Expression Profiling
  • Endoderm
 

Citation

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Liu, Y., & Hogan, B. L. M. (2002). Differential gene expression in the distal tip endoderm of the embryonic mouse lung. Gene Expr Patterns, 2(3–4), 229–233. https://doi.org/10.1016/s1567-133x(02)00057-1
Liu, Yuru, and Brigid L. M. Hogan. “Differential gene expression in the distal tip endoderm of the embryonic mouse lung.Gene Expr Patterns 2, no. 3–4 (December 2002): 229–33. https://doi.org/10.1016/s1567-133x(02)00057-1.
Liu Y, Hogan BLM. Differential gene expression in the distal tip endoderm of the embryonic mouse lung. Gene Expr Patterns. 2002 Dec;2(3–4):229–33.
Liu, Yuru, and Brigid L. M. Hogan. “Differential gene expression in the distal tip endoderm of the embryonic mouse lung.Gene Expr Patterns, vol. 2, no. 3–4, Dec. 2002, pp. 229–33. Pubmed, doi:10.1016/s1567-133x(02)00057-1.
Liu Y, Hogan BLM. Differential gene expression in the distal tip endoderm of the embryonic mouse lung. Gene Expr Patterns. 2002 Dec;2(3–4):229–233.
Journal cover image

Published In

Gene Expr Patterns

DOI

ISSN

1567-133X

Publication Date

December 2002

Volume

2

Issue

3-4

Start / End Page

229 / 233

Location

Netherlands

Related Subject Headings

  • Transcription Factors
  • Thrombospondin 1
  • Signal Transduction
  • Receptors, Cell Surface
  • Protein Transport
  • Mice
  • Lung
  • Ligands
  • Gene Expression Profiling
  • Endoderm