Skip to main content
Journal cover image

Genes of innate immunity and the biological response to inhaled ozone.

Publication ,  Journal Article
Li, Z; Tighe, RM; Feng, F; Ledford, JG; Hollingsworth, JW
Published in: J Biochem Mol Toxicol
January 2013

Ambient ozone has a significant impact on human health. We have made considerable progress in understanding the fundamental mechanisms that regulate the biological response to ozone. It is increasingly clear that genes of innate immunity play a central role in both infectious and noninfectious lung disease. The biological response to ambient ozone provides a clinically relevant environmental exposure that allows us to better understand the role of innate immunity in noninfectious airways disease. In this brief review, we focus on (1) specific cell types in the lung modified by ozone, (2) ozone and oxidative stress, (3) the relationship between genes of innate immunity and ozone, (4) the role of extracellular matrix in reactive airways disease, and (5) the effect of ozone on the adaptive immune system. We summarize recent advances in understanding the mechanisms that ozone contributes to environmental airways disease.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Biochem Mol Toxicol

DOI

EISSN

1099-0461

Publication Date

January 2013

Volume

27

Issue

1

Start / End Page

3 / 16

Location

United States

Related Subject Headings

  • Toxicology
  • Toll-Like Receptors
  • Ozone
  • Oxidative Stress
  • Lung
  • Immunity, Innate
  • Humans
  • Extracellular Matrix
  • Administration, Inhalation
  • Adaptive Immunity
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, Z., Tighe, R. M., Feng, F., Ledford, J. G., & Hollingsworth, J. W. (2013). Genes of innate immunity and the biological response to inhaled ozone. J Biochem Mol Toxicol, 27(1), 3–16. https://doi.org/10.1002/jbt.21453
Li, Zhuowei, Robert M. Tighe, Feifei Feng, Julie G. Ledford, and John W. Hollingsworth. “Genes of innate immunity and the biological response to inhaled ozone.J Biochem Mol Toxicol 27, no. 1 (January 2013): 3–16. https://doi.org/10.1002/jbt.21453.
Li Z, Tighe RM, Feng F, Ledford JG, Hollingsworth JW. Genes of innate immunity and the biological response to inhaled ozone. J Biochem Mol Toxicol. 2013 Jan;27(1):3–16.
Li, Zhuowei, et al. “Genes of innate immunity and the biological response to inhaled ozone.J Biochem Mol Toxicol, vol. 27, no. 1, Jan. 2013, pp. 3–16. Pubmed, doi:10.1002/jbt.21453.
Li Z, Tighe RM, Feng F, Ledford JG, Hollingsworth JW. Genes of innate immunity and the biological response to inhaled ozone. J Biochem Mol Toxicol. 2013 Jan;27(1):3–16.
Journal cover image

Published In

J Biochem Mol Toxicol

DOI

EISSN

1099-0461

Publication Date

January 2013

Volume

27

Issue

1

Start / End Page

3 / 16

Location

United States

Related Subject Headings

  • Toxicology
  • Toll-Like Receptors
  • Ozone
  • Oxidative Stress
  • Lung
  • Immunity, Innate
  • Humans
  • Extracellular Matrix
  • Administration, Inhalation
  • Adaptive Immunity