Rapid relief of severe major depressive disorder by use of preoperative ketamine and electroconvulsive therapy.

Journal Article (Journal Article)

Major depressive disorder is a difficult-to-treat and recurrent debilitating disorder. All approved somatic treatments for major depression to date require a significant time lapse before demonstrating an antidepressant effect. However, emerging evidence indicates a potential role for the use of ketamine to rapidly relieve symptoms of major depression. We present a case of severe, recurrent major depressive disorder that demonstrated marked improvement within 8 hours of receiving a preoperative dose of ketamine and 1 treatment of electroconvulsive therapy with bitemporal electrode placement. This case is supportive of a role of ketamine in relieving symptoms of major depressive disorder rapidly and safely.

Full Text

Duke Authors

Cited Authors

  • Goforth, HW; Holsinger, T

Published Date

  • March 2007

Published In

Volume / Issue

  • 23 / 1

Start / End Page

  • 23 - 25

PubMed ID

  • 17435569

Pubmed Central ID

  • 17435569

International Standard Serial Number (ISSN)

  • 1095-0680

Digital Object Identifier (DOI)

  • 10.1097/01.yct.0000263257.44539.23


  • eng

Conference Location

  • United States