Novel partitioning of DNA cleavage sites for Drosophila topoisomerase II.


Journal Article

We have examined the long-range distribution of double-stranded DNA cleavage sites for Drosophila melanogaster topoisomerase II. These studies reveal a novel partitioning of preferred topoisomerase II cleavage sites. In the eukaryotic DNAs examined, major cleavage sites were typically found in nontranscribed spacer segments and close to the 5' and 3' boundaries of genes. In contrast, there were few if any prominent cleavage sites within genes. In addition, most of the major topoisomerase II cleavage sites closely corresponded to naked DNA hypersensitive sites for the prokaryotic enzyme, micrococcal nuclease.

Full Text

Cited Authors

  • Udvardy, A; Schedl, P; Sander, M; Hsieh, TS

Published Date

  • April 1985

Published In

Volume / Issue

  • 40 / 4

Start / End Page

  • 933 - 941

PubMed ID

  • 2985270

Pubmed Central ID

  • 2985270

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(85)90353-8


  • eng

Conference Location

  • United States