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Effect of thimerosal in leukemia, in leukemic cell lines, and on normal hematopoiesis.

Publication ,  Journal Article
Panella, TJ; Huang, AT
Published in: Cancer Res
July 15, 1990

Anti-thymocyte globulin (ATG), a horse antiserum to human thymus tissue, has been shown to induce granulocytic differentiation of the HL-60 human leukemia cell line. In this paper we describe the effect of ATG on leukemic blasts and its effect on other human leukemia cell lines in vitro. The in vitro differentiation effect of ATG was observed in blasts from two patients with leukemia and the human leukemia cell line K562. The differentiation effect of ATG was attributable to its preservative, thimerosal, separable from ATG by high pressure liquid chromatography or dialysis. Subsequent studies with thimerosal alone showed it to induce differentiation in leukemic blasts from three patients and the human leukemia cell lines U937, K562, and KG-1. The differentiation effect of thimerosal is blocked by a sulfhydryl-protective agent, dithiothreitol, suggesting that the mechanism of differentiation may be mediated via a sulfhydryl group-dependent process.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

July 15, 1990

Volume

50

Issue

14

Start / End Page

4429 / 4435

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Thymidine
  • Thimerosal
  • Oncology & Carcinogenesis
  • Leukemia
  • Humans
  • Hemoglobins
  • Hematopoietic Stem Cells
  • Hematopoiesis
  • Ethylmercury Compounds
 

Citation

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MLA
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Panella, T. J., & Huang, A. T. (1990). Effect of thimerosal in leukemia, in leukemic cell lines, and on normal hematopoiesis. Cancer Res, 50(14), 4429–4435.
Panella, T. J., and A. T. Huang. “Effect of thimerosal in leukemia, in leukemic cell lines, and on normal hematopoiesis.Cancer Res 50, no. 14 (July 15, 1990): 4429–35.
Panella TJ, Huang AT. Effect of thimerosal in leukemia, in leukemic cell lines, and on normal hematopoiesis. Cancer Res. 1990 Jul 15;50(14):4429–35.
Panella, T. J., and A. T. Huang. “Effect of thimerosal in leukemia, in leukemic cell lines, and on normal hematopoiesis.Cancer Res, vol. 50, no. 14, July 1990, pp. 4429–35.
Panella TJ, Huang AT. Effect of thimerosal in leukemia, in leukemic cell lines, and on normal hematopoiesis. Cancer Res. 1990 Jul 15;50(14):4429–4435.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

July 15, 1990

Volume

50

Issue

14

Start / End Page

4429 / 4435

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Thymidine
  • Thimerosal
  • Oncology & Carcinogenesis
  • Leukemia
  • Humans
  • Hemoglobins
  • Hematopoietic Stem Cells
  • Hematopoiesis
  • Ethylmercury Compounds