Extranodal head and neck lymphoma. Prognosis and patterns of recurrence.


Journal Article

Stages I and II extranodal head and neck lymphomas treated between 1969 and 1986 were reviewed to determine prognosis and recurrence patterns. Forty-four patients had low-grade lymphoma, with 57% remaining disease free (median survival, 7.2 years). Radiotherapy provided long-term disease-free survival and palliation in the majority of patients. Relapse did not adversely affect survival. Eighty-eight patients had intermediate- or high-grade lymphoma, with 42% remaining disease free (median survival, 2.4 years). Treatment with radiotherapy alone was inadequate. Combined radiotherapy and anthracycline-containing chemotherapy appeared to be superior. Extranodal sites of first relapse were common. Central nervous system relapse was common with primary tumors located above the pterygopalatine line. Central nervous system staging and prophylactic therapy is warranted in patients with tumors above the pterygopalatine line.

Full Text

Duke Authors

Cited Authors

  • Burton, GV; Atwater, S; Borowitz, MJ; Huang, AT

Published Date

  • January 1990

Published In

Volume / Issue

  • 116 / 1

Start / End Page

  • 69 - 73

PubMed ID

  • 2294944

Pubmed Central ID

  • 2294944

International Standard Serial Number (ISSN)

  • 0886-4470

Digital Object Identifier (DOI)

  • 10.1001/archotol.1990.01870010073021


  • eng

Conference Location

  • United States