Transformation of hairy cell leukemia to EBV genome-containing aggressive B cell lymphoma.

Journal Article (Journal Article)

Hairy cell leukemia is a preplasmacytic B cell leukemia which is not EBV associated, although elevated titers of Epstein-Barr virus (EBV) antibodies have been seen in this leukemia and chronic lymphocytic leukemia. Hairy cells are not readily susceptible to EBV infection in vitro, even though they are EBV receptor-positive B cells. We have observed a 59-year-old patient who after 9 years of hairy cell leukemia developed a well-differentiated IgG-kappa monoclonal B cell lymphoma without further evidence of hairy cell leukemia. Pathologically, the lymphoma showed plasmacytic differentiation, and in the patient's serum, a 2 g/dl monoclonal IgG-kappa component was present. DNA extracted from the lymphomatous lymph node hybridized with DNA fragments of a reiterated sequence of EBV, IR1. The transformation, with no chemotherapy involved, from a preplasmacytic leukemia into a lymphoplasmacytic lymphoma with monoclonal gammopathy may be related to the entry of EBV into these cells. Studies at the molecular level may help understand mechanisms of malignant transformation or interconversion in lymphoproliferative disorders of the B cell type.

Full Text

Duke Authors

Cited Authors

  • Huang, AT; Silverstein, L; Gonias, SL; Rundles, RW; Raab-Traub, N

Published Date

  • April 1, 1987

Published In

Volume / Issue

  • 1 / 4

Start / End Page

  • 369 - 372

PubMed ID

  • 2823016

International Standard Serial Number (ISSN)

  • 0887-6924


  • eng

Conference Location

  • England