Failure of Splenectomy in Felty#x0027; s Syndrome: The Role of Antibodies Supporting Granulocyte Lysis by Lymphocytes
AUTOANTIBODIES may damage human cells through a variety of mechanisms, including complement activation and IgG-dependent phagocytosis. 1 Antibodies can also cause lysis of cells by lymphocytes. This lymphocyte-mediated cytotoxicity depends on IgG antibody and a non-T, non-B, non-“natural-killer” lymphocyte, 2,3 and it has been implicated in the pathophysiology of chronic liver disease, 4 Hashimoto#x0027; s thyroiditis, 5 and the rejection of renal allografts 6,7 and tumors. 8,9 In a previous study, we found that antibodies from some patients with immune neutropenia cause lysis of granulocytes by lymphocytes (antibody-dependent, lymphocyte-mediated granulocytotoxicity or ADLG). 10 We studied 16 patients with Felty#x0027; s syndrome treated with splenectomy, six of whom had no. . . © 1981, Massachusetts Medical Society. All rights reserved.
Logue, GL; Huang, AT; Shimm, DS
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