Microwave treatment of intracerebral L1210 leukemia: schedule-dependent partial reversal of the effects of methotrexate.

Journal Article (Journal Article)

One-GHz microwave (MW) irradiation at a power density of 5 mW/cm2 was combined with methotrexate (MTX) in an attempt to treat more effectively central nervous system (CNS) L1210 leukemia in DBA/2J mice. When mice with CNS leukemia were treated with the combination of MW and MTX, there was no improvement in survival compared with a group of animals treated with MTX alone; however, the group that received MTX before the MW exposure had a significantly reduced survival time compared with the group treated with MTX alone or with the group to which MTX was administered after MW.

Full Text

Duke Authors

Cited Authors

  • Chang, BK; Huang, AT; Joines, WT

Published Date

  • 1981

Published In

Volume / Issue

  • 2 / 1

Start / End Page

  • 77 - 80

PubMed ID

  • 7284044

International Standard Serial Number (ISSN)

  • 0197-8462

Digital Object Identifier (DOI)

  • 10.1002/bem.2250020109


  • eng

Conference Location

  • United States