Immunologic and hematopoietic alterations by 2,450-MHz electromagnetic radiation.

Journal Article (Journal Article)

A biphasic modulation of responsiveness of spleen lymphocytes to mitogens was observed in mice exposed to 2,450-MHz radiation at power densities of 5-15 mW/cm2 over various periods ranging between one and 17 days. This modulated phenomenon may be explained on the basis of 1) suppression of lymphocyte response to microwave-activated macrophages which persists throughout the entire course of radiation, and 2) concurrent progressive direct stimulation of lymphocytes which culminates around day 9 of exposure. Tumor cytotoxicity of killer lymphocytes from mice exposed to five or nine days of radiation did not appear different from sham controls. The highly proliferative hematopoietic marrow cells were sensitive to microwave radiation. Nine days of exposure to radiation (15 mW/cm2) reduced the colony-forming units of myeloid and erythroid series by 50%. This observation may offer a new and more sensitive assay for studying biological effects of electromagnetic radiation.

Full Text

Duke Authors

Cited Authors

  • Huang, AT; Mold, NG

Published Date

  • 1980

Published In

Volume / Issue

  • 1 / 1

Start / End Page

  • 77 - 87

PubMed ID

  • 6974550

International Standard Serial Number (ISSN)

  • 0197-8462

Digital Object Identifier (DOI)

  • 10.1002/bem.2250010108


  • eng

Conference Location

  • United States