3′,4′-Di-o-(-)-camphanoyl-(+)-ciskhellactone and related compounds: A. new class of potent anti-HIV agents

Journal Article

Dihydroseselin type pyranocumarin derivatives were synthesized based on the discovery that suksdorfin (1) was isolated from Lomatium saksdorfii as an anti-HIV agent. Compound 2 demonstrated extremely potent inhibitory activity against HIV-1 replication in H9 lymphocyte cells with an EC50 value of 0.00041 μM and therapeutic index range of > 78,049 but < 390,244. © 1994.

Duke Authors

Cited Authors

  • Huang, L; Kashiwada, Y; Cosentino, LM; Fan, S; Lee, K-H

Published Date

  • 1994

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 593 - 598

International Standard Serial Number (ISSN)

  • 0960-894X