3′,4′-Di-o-(-)-camphanoyl-(+)-ciskhellactone and related compounds: A. new class of potent anti-HIV agents
Journal Article (Journal Article)
Dihydroseselin type pyranocumarin derivatives were synthesized based on the discovery that suksdorfin (1) was isolated from Lomatium saksdorfii as an anti-HIV agent. Compound 2 demonstrated extremely potent inhibitory activity against HIV-1 replication in H9 lymphocyte cells with an EC50 value of 0.00041 μM and therapeutic index range of > 78,049 but < 390,244. © 1994.
Full Text
Duke Authors
Cited Authors
- Huang, L; Kashiwada, Y; Cosentino, LM; Fan, S; Lee, KH
Published Date
- February 24, 1994
Published In
Volume / Issue
- 4 / 4
Start / End Page
- 593 - 598
International Standard Serial Number (ISSN)
- 0960-894X
Digital Object Identifier (DOI)
- 10.1016/S0960-894X(01)80161-X
Citation Source
- Scopus