3′,4′-Di-o-(-)-camphanoyl-(+)-ciskhellactone and related compounds: A. new class of potent anti-HIV agents
Dihydroseselin type pyranocumarin derivatives were synthesized based on the discovery that suksdorfin (1) was isolated from Lomatium saksdorfii as an anti-HIV agent. Compound 2 demonstrated extremely potent inhibitory activity against HIV-1 replication in H9 lymphocyte cells with an EC50 value of 0.00041 μM and therapeutic index range of > 78,049 but < 390,244. © 1994.
Huang, L; Kashiwada, Y; Cosentino, LM; Fan, S; Lee, KH
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