New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C.
Journal Article (Journal Article)
We have previously shown that some ellagitannins are potent inhibitors of protein kinase C (PKC). On the basis of this finding, several series of hexahydroxybiphenyl derivatives of ellagic acid were synthesized as simple analogs of these ellagitannins and were evaluated for their inhibitory effect against PKC. Compounds 23 and 26 were found to be potent inhibitors of PKC, while hexakis-(benzyloxy)biphenyl derivatives exhibited weak anti-PKC activity.
Full Text
Duke Authors
Cited Authors
- Kashiwada, Y; Huang, L; Ballas, LM; Jiang, JB; Janzen, WP; Lee, KH
Published Date
- January 7, 1994
Published In
Volume / Issue
- 37 / 1
Start / End Page
- 195 - 200
PubMed ID
- 8289196
International Standard Serial Number (ISSN)
- 0022-2623
Digital Object Identifier (DOI)
- 10.1021/jm00027a025
Language
- eng
Conference Location
- United States