New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C.


Journal Article

We have previously shown that some ellagitannins are potent inhibitors of protein kinase C (PKC). On the basis of this finding, several series of hexahydroxybiphenyl derivatives of ellagic acid were synthesized as simple analogs of these ellagitannins and were evaluated for their inhibitory effect against PKC. Compounds 23 and 26 were found to be potent inhibitors of PKC, while hexakis-(benzyloxy)biphenyl derivatives exhibited weak anti-PKC activity.

Full Text

Duke Authors

Cited Authors

  • Kashiwada, Y; Huang, L; Ballas, LM; Jiang, JB; Janzen, WP; Lee, KH

Published Date

  • January 1, 1994

Published In

Volume / Issue

  • 37 / 1

Start / End Page

  • 195 - 200

PubMed ID

  • 8289196

Pubmed Central ID

  • 8289196

Electronic International Standard Serial Number (EISSN)

  • 1520-4804

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm00027a025


  • eng