The development and function of memory regulatory T cells after acute viral infections.

Published

Journal Article

Natural CD4+CD25+Foxp3+ regulatory T cells (Tregs) are critical for the control of immune responses to pathogens. However, most studies have focused on chronic infections, in which pathogen-specific Tregs contribute to pathogen persistence and, in some cases, concomitant immunity. How Tregs behave and function following acute infections remains largely unknown. In this article, we show that pathogen-specific Tregs can be activated and expand upon acute viral infections in vivo. The activated Tregs then contract to form a memory pool after resolution of the infection. These memory Tregs expand rapidly upon a secondary challenge, secrete large amounts of IL-10, and suppress excessive immunopathological conditions elicited by recall expansion of non-Tregs via an IL-10-dependent mechanism. Our work reveals a memory Treg population that develops after acute viral infections and may help in the design of effective strategies to circumvent excessive immunopathological effects.

Full Text

Cited Authors

  • Sanchez, AM; Zhu, J; Huang, X; Yang, Y

Published Date

  • September 15, 2012

Published In

Volume / Issue

  • 189 / 6

Start / End Page

  • 2805 - 2814

PubMed ID

  • 22855712

Pubmed Central ID

  • 22855712

Electronic International Standard Serial Number (EISSN)

  • 1550-6606

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.1200645

Language

  • eng

Conference Location

  • United States