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Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo.

Publication ,  Journal Article
Martinez, J; Huang, X; Yang, Y
Published in: Journal of immunology (Baltimore, Md. : 1950)
February 2008

Type I IFN plays an important role in the activation of NK cells. However, the mechanism underlying type I IFN-dependent NK cell activation remains largely unknown. A recent report suggested that type I IFN acted on accessory dendritic cells, leading to IL-15 production, and that subsequent trans-presentation of IL-15 was required for NK cell activation upon stimulation with synthetic TLR ligands. It is not clear how type I IFN regulates NK cell activation in response to live pathogens. Using a murine model of infection with vaccinia virus (VV), we previously demonstrated a critical role for type I IFN in the innate immune control of VV infection. In this study, we first showed that type I IFN did not directly protect L929 cells from VV infection in vitro and that type I IFN-dependent innate immune control of VV infection in vivo was mediated by activated NK cells. We further demonstrated that direct action of type I IFN on NK cells, but not on dendritic cells, is required for the activation of NK cells in response to VV infection both in vitro and in vivo, leading to efficient VV clearance. Our findings may help design effective strategies for the control of poxviral infections in vivo.

Published In

Journal of immunology (Baltimore, Md. : 1950)

DOI

EISSN

1550-6606

ISSN

0022-1767

Publication Date

February 2008

Volume

180

Issue

3

Start / End Page

1592 / 1597

Related Subject Headings

  • Vaccinia
  • Mice, Mutant Strains
  • Mice
  • Lymphocyte Activation
  • Killer Cells, Natural
  • Interferon Type I
  • Immunology
  • Immunity, Innate
  • Animals
  • 3204 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Martinez, J., Huang, X., & Yang, Y. (2008). Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo. Journal of Immunology (Baltimore, Md. : 1950), 180(3), 1592–1597. https://doi.org/10.4049/jimmunol.180.3.1592
Martinez, Jennifer, Xiaopei Huang, and Yiping Yang. “Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo.Journal of Immunology (Baltimore, Md. : 1950) 180, no. 3 (February 2008): 1592–97. https://doi.org/10.4049/jimmunol.180.3.1592.
Martinez J, Huang X, Yang Y. Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo. Journal of immunology (Baltimore, Md : 1950). 2008 Feb;180(3):1592–7.
Martinez, Jennifer, et al. “Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo.Journal of Immunology (Baltimore, Md. : 1950), vol. 180, no. 3, Feb. 2008, pp. 1592–97. Epmc, doi:10.4049/jimmunol.180.3.1592.
Martinez J, Huang X, Yang Y. Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo. Journal of immunology (Baltimore, Md : 1950). 2008 Feb;180(3):1592–1597.

Published In

Journal of immunology (Baltimore, Md. : 1950)

DOI

EISSN

1550-6606

ISSN

0022-1767

Publication Date

February 2008

Volume

180

Issue

3

Start / End Page

1592 / 1597

Related Subject Headings

  • Vaccinia
  • Mice, Mutant Strains
  • Mice
  • Lymphocyte Activation
  • Killer Cells, Natural
  • Interferon Type I
  • Immunology
  • Immunity, Innate
  • Animals
  • 3204 Immunology