STAT1 signaling in CD8 T cells is required for their clonal expansion and memory formation following viral infection in vivo.

Published

Journal Article

Recent advances have shown that direct type I IFN signaling on T cells is required for their efficient expansion in response to viral infections in vivo. It is not clear which intracellular signaling molecule is responsible for this effect. Although STAT1 has been shown to mediate many of the type I IFN-dependent biological effects, its role in T cells remains uncertain in vivo. In this study, we demonstrated that STAT1 signaling in CD8 T cells was required for their efficient expansion by promoting the survival of activated CD8 T cells upon vaccinia viral infection in vivo, suggesting that the direct effect of type I IFNs on CD8 T cells is mediated by STAT1. Furthermore, effector CD8 T cells that lack STAT1 signaling did not survive the contraction phase to differentiate into long-lived memory cells. These results identify a critical role for type I IFN-STAT1 signaling in multiple stages of CD8 T cell response in vivo and suggest that strategies to activate type I IFN-STAT1 signaling pathway may enhance vaccine potency.

Full Text

Duke Authors

Cited Authors

  • Quigley, M; Huang, X; Yang, Y

Published Date

  • February 15, 2008

Published In

Volume / Issue

  • 180 / 4

Start / End Page

  • 2158 - 2164

PubMed ID

  • 18250422

Pubmed Central ID

  • 18250422

International Standard Serial Number (ISSN)

  • 0022-1767

Language

  • eng

Conference Location

  • United States