Opioid-induced hyperalgesia: a review of epidemiology, mechanisms and management.


Journal Article (Review)

There has been a growing interest in opioid-induced hyperalgesia (OIH), which is an increased sensitivity to pain caused by opioid exposure. Multiple underlying pathways may contribute to the development of OIH, and the mechanism may vary with the duration of opioid exposure, dose, type and route of administration. In addition, the distinction between OIH, tolerance and withdrawal should be made in both the basic and clinical science literature so as to help translate findings to the clinical phenomenon and to help determine the best strategies to prevent or treat OIH.

Full Text

Cited Authors

  • Low, Y; Clarke, CF; Huh, BK

Published Date

  • May 2012

Published In

Volume / Issue

  • 53 / 5

Start / End Page

  • 357 - 360

PubMed ID

  • 22584979

Pubmed Central ID

  • 22584979

International Standard Serial Number (ISSN)

  • 0037-5675


  • eng