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Weight loss in narcolepsy patients treated with sodium oxybate.

Publication ,  Journal Article
Husain, AM; Ristanovic, RK; Bogan, RK
Published in: Sleep Med
June 2009

INTRODUCTION: Narcolepsy is often associated with increased body weight. Sodium oxybate has efficacy in many narcolepsy symptoms. The purpose of this study was to evaluate the effects of sodium oxybate on weight in patients with narcolepsy. METHODS: Charts from three centers of all patients with narcolepsy who had been using sodium oxybate for at least 3 months were reviewed. Patients in whom anti-cataplexy medications were added or withdrawn or wake-promoting medications added after the start of sodium oxybate were excluded from further analysis. In the remainder, pre-sodium oxybate and, most recently, on-sodium oxybate weights were compared using Student's t-tests. Sodium oxybate dose and duration of therapy were also noted. RESULTS: A total of 54 patients meeting inclusion criteria were identified. Of these 54, 33 (61%) were women; the mean age was 48.3 years. The mean dose of sodium oxybate was 6.9g/night and the duration of therapy was 25 months. The mean pre-sodium oxybate weight was 78.3 (+/-15.7)kg. The most recent on-sodium oxybate weight was 74.9 (+/-15.1, p=0.003). The average weight loss was 3.4kg, whereas the maximum was 30.9kg. CONCLUSIONS: This study suggests that treatment of patients with narcolepsy with sodium oxybate can result in weight loss.

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Published In

Sleep Med

DOI

EISSN

1878-5506

Publication Date

June 2009

Volume

10

Issue

6

Start / End Page

661 / 663

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Weight Loss
  • Sodium Oxybate
  • Retrospective Studies
  • Neurology & Neurosurgery
  • Narcolepsy
  • Middle Aged
  • Male
  • Humans
  • Female
 

Citation

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Husain, A. M., Ristanovic, R. K., & Bogan, R. K. (2009). Weight loss in narcolepsy patients treated with sodium oxybate. Sleep Med, 10(6), 661–663. https://doi.org/10.1016/j.sleep.2008.05.012
Husain, Aatif M., Ruzica K. Ristanovic, and Richard K. Bogan. “Weight loss in narcolepsy patients treated with sodium oxybate.Sleep Med 10, no. 6 (June 2009): 661–63. https://doi.org/10.1016/j.sleep.2008.05.012.
Husain AM, Ristanovic RK, Bogan RK. Weight loss in narcolepsy patients treated with sodium oxybate. Sleep Med. 2009 Jun;10(6):661–3.
Husain, Aatif M., et al. “Weight loss in narcolepsy patients treated with sodium oxybate.Sleep Med, vol. 10, no. 6, June 2009, pp. 661–63. Pubmed, doi:10.1016/j.sleep.2008.05.012.
Husain AM, Ristanovic RK, Bogan RK. Weight loss in narcolepsy patients treated with sodium oxybate. Sleep Med. 2009 Jun;10(6):661–663.
Journal cover image

Published In

Sleep Med

DOI

EISSN

1878-5506

Publication Date

June 2009

Volume

10

Issue

6

Start / End Page

661 / 663

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Weight Loss
  • Sodium Oxybate
  • Retrospective Studies
  • Neurology & Neurosurgery
  • Narcolepsy
  • Middle Aged
  • Male
  • Humans
  • Female