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Tuberous sclerosis complex and epilepsy: prognostic significance of electroencephalography and magnetic resonance imaging.

Publication ,  Journal Article
Husain, AM; Foley, CM; Legido, A; Chandler, DA; Miles, DK; Grover, WD
Published in: J Child Neurol
February 2000

Tuberous sclerosis complex is a disease that affects many organs, including the central nervous system. Nervous system involvement in the form of hamartomas often results in seizures. In this study we wanted to determine the outcome of epilepsy in tuberous sclerosis complex and determine whether interictal electroencephalograms (EEGs) and hamartoma burden as seen with magnetic resonance imaging (MRI) are predictive of degree of seizure control. The study population consisted of 30 patients. For each patient two sets of EEG and MRI data, separated by at least 12 months, and information on seizure frequency at time of data collection were obtained. Sensitivity, specificity, and positive and negative predictive values of various EEG and MRI findings were determined. Seizure control improved in 20 and worsened in 10 patients. In relation to seizure control, the specificity of an abnormal sleep EEG and the positive predictive value of normal sleep EEG were 100%. MRI and EEG background were neither sensitive nor specific for predicting seizure control. A majority of children with tuberous sclerosis complex can achieve good seizure control. The sleep EEG is helpful in predicting eventual seizure control.

Duke Scholars

Published In

J Child Neurol

DOI

ISSN

0883-0738

Publication Date

February 2000

Volume

15

Issue

2

Start / End Page

81 / 83

Location

United States

Related Subject Headings

  • Tuberous Sclerosis
  • Severity of Illness Index
  • Prospective Studies
  • Predictive Value of Tests
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Infant
  • Humans
  • Hamartoma
 

Citation

APA
Chicago
ICMJE
MLA
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Husain, A. M., Foley, C. M., Legido, A., Chandler, D. A., Miles, D. K., & Grover, W. D. (2000). Tuberous sclerosis complex and epilepsy: prognostic significance of electroencephalography and magnetic resonance imaging. J Child Neurol, 15(2), 81–83. https://doi.org/10.1177/088307380001500203
Husain, A. M., C. M. Foley, A. Legido, D. A. Chandler, D. K. Miles, and W. D. Grover. “Tuberous sclerosis complex and epilepsy: prognostic significance of electroencephalography and magnetic resonance imaging.J Child Neurol 15, no. 2 (February 2000): 81–83. https://doi.org/10.1177/088307380001500203.
Husain AM, Foley CM, Legido A, Chandler DA, Miles DK, Grover WD. Tuberous sclerosis complex and epilepsy: prognostic significance of electroencephalography and magnetic resonance imaging. J Child Neurol. 2000 Feb;15(2):81–3.
Husain, A. M., et al. “Tuberous sclerosis complex and epilepsy: prognostic significance of electroencephalography and magnetic resonance imaging.J Child Neurol, vol. 15, no. 2, Feb. 2000, pp. 81–83. Pubmed, doi:10.1177/088307380001500203.
Husain AM, Foley CM, Legido A, Chandler DA, Miles DK, Grover WD. Tuberous sclerosis complex and epilepsy: prognostic significance of electroencephalography and magnetic resonance imaging. J Child Neurol. 2000 Feb;15(2):81–83.
Journal cover image

Published In

J Child Neurol

DOI

ISSN

0883-0738

Publication Date

February 2000

Volume

15

Issue

2

Start / End Page

81 / 83

Location

United States

Related Subject Headings

  • Tuberous Sclerosis
  • Severity of Illness Index
  • Prospective Studies
  • Predictive Value of Tests
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Infant
  • Humans
  • Hamartoma