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Generalized periodic epileptiform discharges: etiologies, relationship to status epilepticus, and prognosis.

Publication ,  Journal Article
Husain, AM; Mebust, KA; Radtke, RA
Published in: J Clin Neurophysiol
January 1999

Generalized periodic epileptiform discharges (GPEDs) are generalized, synchronous electrographic discharges. This study investigates etiologies, relationship to status epilepticus (SE), and the prognosis for patients with GPEDs. All EEGs with GPEDs performed at Duke University Medical Center between January 1994 and October 1995 were identified. Clinical histories and EEGs were reviewed. They were divided into groups depending on the etiology of the GPEDs, whether the patients were in SE or not, and whether they were alive or not at discharge. A comparison of histories and GPED characteristics among groups was undertaken using parametric and nonparametric t tests. Twenty-five patients were enrolled: 7 (28%) had toxic-metabolic encephalopathy, 10 (40%) had anoxia and toxic-metabolic encephalopathy, and 8 (32%) had a primary neurologic process. Eight patients (32%) were in SE. In the SE group, GPED amplitude was higher (110 versus 80 microV, P < 0.05), GPED duration was longer (0.5 versus 0.3 seconds, P < 0.05), and inter-GPED amplitude was higher (34 versus 17 microV, P < 0.05). Nine patients (36%) were alive at discharge; they were more likely to be younger (51 versus 68 years, P < 0.05), have a better mental status at the time of their EEG, and have a higher inter-GPED amplitude (33 versus 18 microV, P < 0.05). A variety of conditions, including SE, can cause GPEDs. Intergroup differences in historic and GPED features exist between those patients in SE and those not in SE and those with good and poor prognoses.

Duke Scholars

Published In

J Clin Neurophysiol

DOI

ISSN

0736-0258

Publication Date

January 1999

Volume

16

Issue

1

Start / End Page

51 / 58

Location

United States

Related Subject Headings

  • Status Epilepticus
  • Prognosis
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Female
  • Epilepsy, Generalized
  • Electroencephalography
  • Aged, 80 and over
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Husain, A. M., Mebust, K. A., & Radtke, R. A. (1999). Generalized periodic epileptiform discharges: etiologies, relationship to status epilepticus, and prognosis. J Clin Neurophysiol, 16(1), 51–58. https://doi.org/10.1097/00004691-199901000-00005
Husain, A. M., K. A. Mebust, and R. A. Radtke. “Generalized periodic epileptiform discharges: etiologies, relationship to status epilepticus, and prognosis.J Clin Neurophysiol 16, no. 1 (January 1999): 51–58. https://doi.org/10.1097/00004691-199901000-00005.
Husain AM, Mebust KA, Radtke RA. Generalized periodic epileptiform discharges: etiologies, relationship to status epilepticus, and prognosis. J Clin Neurophysiol. 1999 Jan;16(1):51–8.
Husain, A. M., et al. “Generalized periodic epileptiform discharges: etiologies, relationship to status epilepticus, and prognosis.J Clin Neurophysiol, vol. 16, no. 1, Jan. 1999, pp. 51–58. Pubmed, doi:10.1097/00004691-199901000-00005.
Husain AM, Mebust KA, Radtke RA. Generalized periodic epileptiform discharges: etiologies, relationship to status epilepticus, and prognosis. J Clin Neurophysiol. 1999 Jan;16(1):51–58.

Published In

J Clin Neurophysiol

DOI

ISSN

0736-0258

Publication Date

January 1999

Volume

16

Issue

1

Start / End Page

51 / 58

Location

United States

Related Subject Headings

  • Status Epilepticus
  • Prognosis
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Female
  • Epilepsy, Generalized
  • Electroencephalography
  • Aged, 80 and over