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Evaluating the feasibility of extended partial mastectomy and immediate reduction mammoplasty reconstruction as an alternative to mastectomy.

Publication ,  Journal Article
Chang, EI; Peled, AW; Foster, RD; Lin, C; Zeidler, KR; Ewing, CA; Alvarado, M; Hwang, ES; Esserman, LJ
Published in: Ann Surg
June 2012

OBJECTIVES: To assess the efficacy of using concurrent partial mastectomy and reduction mammoplasty for resection of a wide range of tumor sizes and compare oncologic outcomes and postoperative complications on the basis of tumor size. BACKGROUND: Although tumor size greater than 4 cm has been considered an indication for undergoing a mastectomy, this dictum may not apply in women with breast hypertrophy, where the ratio of tumor size to breast size may still permit breast conservation. We wished to evaluate whether an approach combining partial mastectomy with reduction mammoplasty could provide a safe oncologic procedure with immediate breast reconstruction that could technically be applied even for large (>4 cm) lesions. METHODS: A retrospective review of all patients undergoing partial mastectomy and concurrent reduction mammoplasty performed at our institution from 2000 to 2009. Clinical characteristics at presentation, pathologic data, and follow-up data were collected and analyzed. RESULTS: Eighty-five consecutive simultaneous partial mastectomy/reduction mammoplasty procedures were performed in 79 patients. Average tumor size was 2.8 cm for ductal carcinoma in situ (0.05-17.0 cm), 2.4 cm for invasive ductal carcinoma (IDC) (0.2-8.9 cm), 3.5 cm for lobular carcinoma (1.6-8.0 cm), and 5.7 cm for phyllodes tumors (3.7-7.6 cm). Twenty-five of 85 tumors (29.4%) were larger than 4 cm. Distribution for stage 0, I, II, III, and IV disease was 15, 12, 35, 19, and 2 tumors respectively, with an additional 2 phyllodes tumors. Median follow-up was 39 months (10-130 months). Seventy-five patients (94.9%) achieved successful breast conservation, whereas 4 patients (5.1%) went on to completion mastectomy. Thirteen patients (16.4%) required 1 reexcision to achieve clear margins, and 2 (2.5%) required multiple reexcisions. Two patients had a local recurrence during the follow-up period, one of whom underwent reexcision and the other underwent mastectomy. The overall complication rate was 14.1%, which included 4 major complications (4.7%) requiring an unplanned return to the operating room and need for hospital readmission, and 8 minor wound-related complications (9.4%). Neither recurrence nor complication rates were increased in patients with tumors greater than 4 cm when compared with tumors less than or equal to 4 cm. CONCLUSIONS: A partial mastectomy with concurrent reduction mammoplasty technique is a viable option for breast conservation even for larger tumors, combining a safe oncologic procedure with excellent cosmesis. A combined effort between breast surgeons and reconstructive surgeons has a high probability of success with low recurrence rates. In carefully selected patients, this approach may be preferable to mastecomy and breast reconstruction, particularly when postmastectomy radiation therapy is anticipated.

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Published In

Ann Surg

DOI

EISSN

1528-1140

Publication Date

June 2012

Volume

255

Issue

6

Start / End Page

1151 / 1157

Location

United States

Related Subject Headings

  • Surgery
  • Retrospective Studies
  • Middle Aged
  • Mastectomy, Segmental
  • Mammaplasty
  • Humans
  • Female
  • Feasibility Studies
  • Breast Neoplasms
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chang, E. I., Peled, A. W., Foster, R. D., Lin, C., Zeidler, K. R., Ewing, C. A., … Esserman, L. J. (2012). Evaluating the feasibility of extended partial mastectomy and immediate reduction mammoplasty reconstruction as an alternative to mastectomy. Ann Surg, 255(6), 1151–1157. https://doi.org/10.1097/SLA.0b013e31824f9769
Chang, Edward I., Anne Warren Peled, Robert D. Foster, Cheryl Lin, Kamakshi R. Zeidler, Cheryl A. Ewing, Michael Alvarado, E Shelley Hwang, and Laura J. Esserman. “Evaluating the feasibility of extended partial mastectomy and immediate reduction mammoplasty reconstruction as an alternative to mastectomy.Ann Surg 255, no. 6 (June 2012): 1151–57. https://doi.org/10.1097/SLA.0b013e31824f9769.
Chang EI, Peled AW, Foster RD, Lin C, Zeidler KR, Ewing CA, et al. Evaluating the feasibility of extended partial mastectomy and immediate reduction mammoplasty reconstruction as an alternative to mastectomy. Ann Surg. 2012 Jun;255(6):1151–7.
Chang, Edward I., et al. “Evaluating the feasibility of extended partial mastectomy and immediate reduction mammoplasty reconstruction as an alternative to mastectomy.Ann Surg, vol. 255, no. 6, June 2012, pp. 1151–57. Pubmed, doi:10.1097/SLA.0b013e31824f9769.
Chang EI, Peled AW, Foster RD, Lin C, Zeidler KR, Ewing CA, Alvarado M, Hwang ES, Esserman LJ. Evaluating the feasibility of extended partial mastectomy and immediate reduction mammoplasty reconstruction as an alternative to mastectomy. Ann Surg. 2012 Jun;255(6):1151–1157.

Published In

Ann Surg

DOI

EISSN

1528-1140

Publication Date

June 2012

Volume

255

Issue

6

Start / End Page

1151 / 1157

Location

United States

Related Subject Headings

  • Surgery
  • Retrospective Studies
  • Middle Aged
  • Mastectomy, Segmental
  • Mammaplasty
  • Humans
  • Female
  • Feasibility Studies
  • Breast Neoplasms
  • 3202 Clinical sciences