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The effect of sentinel node tumor burden on non-sentinel node status and recurrence rates in breast cancer.

Publication ,  Journal Article
Fan, Y-G; Tan, Y-Y; Wu, C-T; Treseler, P; Lu, Y; Chan, C-W; Hwang, S; Ewing, C; Esserman, L; Morita, E; Leong, SPL
Published in: Ann Surg Oncol
September 2005

BACKGROUND: Routine axillary lymph node dissection (ALND) after selective sentinel lymphadenectomy (SSL) in the treatment of breast cancer remains controversial. We sought to determine the need for routine ALND by exploring the relationship between sentinel lymph node (SLN) and non-SLN (NSLN) status. We also report our experience with disease relapse in the era of SSL and attempt to correlate this with SLN tumor burden. METHODS: This was a retrospective study of 390 patients with invasive breast cancer treated at a single institution who underwent successful SSL from November 1997 to November 2002. RESULTS: Of the 390 patients, 115 received both SSL and ALND. The percentage of additional positive NSLNs in the SLN-positive group (34.2%) was significantly higher than in the SLN-negative group (5.1%; P = .0004). The SLN macrometastasis group had a significantly higher rate of positive NSLNs (39.7%) compared with the SLN-negative group (5.1%; P = .0001). Sixteen patients developed recurrences during follow-up, including 6.1% of SLN-positive and 3.3% of SLN-negative patients. Among the SLN macrometastasis group, 8.7% had recurrence, compared with 2.2% of SLN micrometastases over a median follow-up period of 31.1 months. One regional failure developed out of 38 SLN-positive patients who did not undergo ALND. CONCLUSIONS: ALND is recommended for patients with SLN macrometastasis because of a significantly higher incidence of positive NSLNs. Higher recurrence rates are also seen in these patients. However, the role of routine ALND in patients with a low SLN tumor burden remains to be further determined by prospective randomized trials.

Duke Scholars

Published In

Ann Surg Oncol

DOI

ISSN

1068-9265

Publication Date

September 2005

Volume

12

Issue

9

Start / End Page

705 / 711

Location

United States

Related Subject Headings

  • Tumor Burden
  • Treatment Outcome
  • Sentinel Lymph Node Biopsy
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Lymph Nodes
  • Lymph Node Excision
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fan, Y.-G., Tan, Y.-Y., Wu, C.-T., Treseler, P., Lu, Y., Chan, C.-W., … Leong, S. P. L. (2005). The effect of sentinel node tumor burden on non-sentinel node status and recurrence rates in breast cancer. Ann Surg Oncol, 12(9), 705–711. https://doi.org/10.1245/ASO.2005.08.020
Fan, Yang-Guo, Yah-Yuen Tan, Chen-Teng Wu, Patrick Treseler, Ying Lu, Chung-Wei Chan, Shelley Hwang, et al. “The effect of sentinel node tumor burden on non-sentinel node status and recurrence rates in breast cancer.Ann Surg Oncol 12, no. 9 (September 2005): 705–11. https://doi.org/10.1245/ASO.2005.08.020.
Fan Y-G, Tan Y-Y, Wu C-T, Treseler P, Lu Y, Chan C-W, et al. The effect of sentinel node tumor burden on non-sentinel node status and recurrence rates in breast cancer. Ann Surg Oncol. 2005 Sep;12(9):705–11.
Fan, Yang-Guo, et al. “The effect of sentinel node tumor burden on non-sentinel node status and recurrence rates in breast cancer.Ann Surg Oncol, vol. 12, no. 9, Sept. 2005, pp. 705–11. Pubmed, doi:10.1245/ASO.2005.08.020.
Fan Y-G, Tan Y-Y, Wu C-T, Treseler P, Lu Y, Chan C-W, Hwang S, Ewing C, Esserman L, Morita E, Leong SPL. The effect of sentinel node tumor burden on non-sentinel node status and recurrence rates in breast cancer. Ann Surg Oncol. 2005 Sep;12(9):705–711.
Journal cover image

Published In

Ann Surg Oncol

DOI

ISSN

1068-9265

Publication Date

September 2005

Volume

12

Issue

9

Start / End Page

705 / 711

Location

United States

Related Subject Headings

  • Tumor Burden
  • Treatment Outcome
  • Sentinel Lymph Node Biopsy
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Lymph Nodes
  • Lymph Node Excision
  • Humans