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Patterns of chromosomal alterations in breast ductal carcinoma in situ.

Publication ,  Journal Article
Hwang, ES; DeVries, S; Chew, KL; Moore, DH; Kerlikowske, K; Thor, A; Ljung, B-M; Waldman, FM
Published in: Clin Cancer Res
August 1, 2004

PURPOSE: Ductal carcinoma in situ (DCIS) is thought to be a nonobligate precursor of invasive cancer. Genomic changes specific to pure DCIS versus invasive cancer, as well as alterations unique to individual DCIS subtypes, have not been fully defined. EXPERIMENTAL DESIGN: Chromosomal copy number alterations were examined by comparative genomic hybridization in 34 cases of pure DCIS and compared with 12 cases of paired synchronous DCIS and invasive ductal cancer, as well as to 146 additional cases of invasive breast cancer of ductal or lobular histology. Genomic differences between high-grade and low/intermediate-grade DCIS, as well as between pure DCIS and invasive cancer, were identified. RESULTS: Pure DCIS showed almost the same degree of chromosomal instability as invasive ductal cancers. A higher proportion of low/intermediate-grade versus high-grade DCIS had loss of 16q (65 versus 12%, respectively; P = 0.002). When compared with lower grade DCIS, high-grade DCIS exhibited more frequent gain of 17q (65 versus 41%; P = 0.15) and higher frequency loss of 8p (77 versus 41%; P = 0.04). Chromosomal alterations in those cases with synchronous DCIS and invasive ductal cancer showed a high degree of shared changes within the two components. CONCLUSIONS: DCIS is genetically advanced, showing a similar degree of chromosomal alterations as invasive ductal cancer. The pattern of alterations differed between high- and low/intermediate-grade DCIS, supporting a model in which different histological grades of DCIS are associated with distinct genomic changes. These regions of chromosomal alterations may be potential targets for treatment and/or markers of prognosis.

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Published In

Clin Cancer Res

DOI

ISSN

1078-0432

Publication Date

August 1, 2004

Volume

10

Issue

15

Start / End Page

5160 / 5167

Location

United States

Related Subject Headings

  • Time Factors
  • Prognosis
  • Prevalence
  • Oncology & Carcinogenesis
  • Nucleic Acid Hybridization
  • Neoplasm Invasiveness
  • Models, Genetic
  • Middle Aged
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Hwang, E. S., DeVries, S., Chew, K. L., Moore, D. H., Kerlikowske, K., Thor, A., … Waldman, F. M. (2004). Patterns of chromosomal alterations in breast ductal carcinoma in situ. Clin Cancer Res, 10(15), 5160–5167. https://doi.org/10.1158/1078-0432.CCR-04-0165
Hwang, E Shelley, Sandy DeVries, Karen L. Chew, Dan H. Moore, Karla Kerlikowske, Ann Thor, Britt-Marie Ljung, and Frederic M. Waldman. “Patterns of chromosomal alterations in breast ductal carcinoma in situ.Clin Cancer Res 10, no. 15 (August 1, 2004): 5160–67. https://doi.org/10.1158/1078-0432.CCR-04-0165.
Hwang ES, DeVries S, Chew KL, Moore DH, Kerlikowske K, Thor A, et al. Patterns of chromosomal alterations in breast ductal carcinoma in situ. Clin Cancer Res. 2004 Aug 1;10(15):5160–7.
Hwang, E. Shelley, et al. “Patterns of chromosomal alterations in breast ductal carcinoma in situ.Clin Cancer Res, vol. 10, no. 15, Aug. 2004, pp. 5160–67. Pubmed, doi:10.1158/1078-0432.CCR-04-0165.
Hwang ES, DeVries S, Chew KL, Moore DH, Kerlikowske K, Thor A, Ljung B-M, Waldman FM. Patterns of chromosomal alterations in breast ductal carcinoma in situ. Clin Cancer Res. 2004 Aug 1;10(15):5160–5167.

Published In

Clin Cancer Res

DOI

ISSN

1078-0432

Publication Date

August 1, 2004

Volume

10

Issue

15

Start / End Page

5160 / 5167

Location

United States

Related Subject Headings

  • Time Factors
  • Prognosis
  • Prevalence
  • Oncology & Carcinogenesis
  • Nucleic Acid Hybridization
  • Neoplasm Invasiveness
  • Models, Genetic
  • Middle Aged
  • Humans
  • Female