Array-based comparative genomic hybridization of ductal carcinoma in situ and synchronous invasive lobular cancer.

Journal Article (Journal Article)

It has been increasingly recognized that ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive cancer of the breast are often closely associated with one another. However, the genomic relationship between these histologically distinct entities has not been well characterized. Refinements in high-resolution comparative genomic hybridization (CGH) techniques allow for a detailed comparison of genomic alterations in synchronously occurring tumors. The following case illustrates how array CGH may be used to better understand whether synchronous neoplasms share a common origin.

Full Text

Duke Authors

Cited Authors

  • Nyante, SJ; Devries, S; Chen, YY; Hwang, ES

Published Date

  • June 2004

Published In

Volume / Issue

  • 35 / 6

Start / End Page

  • 759 - 763

PubMed ID

  • 15188144

International Standard Serial Number (ISSN)

  • 0046-8177

Digital Object Identifier (DOI)

  • 10.1016/j.humpath.2003.11.009


  • eng

Conference Location

  • United States